What are protein interaction networks?
Protein interaction networks are networks of proteins that interact together in an organism[1]. These interactions can be physical interactions or functional interactions. These interactions can be concluded from databases, computational predictions, or organism knowledge transfer. These networks can be used to further understand the role of a protein within an organism and discover roles in previously unknown processes.
LCT Interaction Network
Homo sapiens (Human) LCT interaction network
Mus musculus (Mouse) LCT interaction network
These two protein interaction networks were constructed using data from databases. There have been no published experiments about the protein interactions of LCT in humans or mice; therefore, there was no protein interaction network from experimental data only .
Conclusions
There are very similar protein interaction networks for human and mouse LCT based on the databases. Most of the interactions are directly or indirectly involved in carbohydrate metabolic processes. However, there is no experimental data for LCT interactions. Future studies should use the mammalian two-hybrid system to experimentally determine LCT protein interactions. The GO terms could then be analyzed to determine which biological processes LCT is involved in. A similar experiment could be performed with mutant R1587H LCT and determine differences in the protein interaction network to elucidate how this mutation affects LCT protein-protein interaction.
References
[1] Snel, B et al. (2000, September). STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res. Retrieved from www.ncbi.nlm.nih.gov/pubmed/10982861
Header image: www.6seconds.org/2017/04/11/neural-network-emotional-intelligence/
[1] Snel, B et al. (2000, September). STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res. Retrieved from www.ncbi.nlm.nih.gov/pubmed/10982861
Header image: www.6seconds.org/2017/04/11/neural-network-emotional-intelligence/